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People who are trying to lose weight may hinder their odds of success by skipping breakfast, according to a new study that found that skipping the first meal of the day biases your brain toward craving high-calorie foods over low-calorie foods.
“When people are fasting — in this case skipping breakfast — this obviously leads to people being hungrier, but it also leads to greater activity in areas of the brain involved in reward,” Dr. Anthony Goldstone from Imperial College London, UK, told The Endocrine Society’s annual meeting in Washington, D.C.
“In addition, we find that when people are fasting they also prefer high-calorie foods to low-calorie foods,” he added.
The findings are based on brain imaging studies performed in 20 non-obese healthy people who were shown pictures of low-calorie foods (salad, vegetables and fish) and high-calorie foods (cake, chocolate, and pizza) and asked to rate how appealing the pictures were after a filling breakfast or after no breakfast at all.
Past studies, Goldstone noted, have shown that people who skip breakfast on a regular basis actually tend to be heavier, tend to get more of their calories from fat, and also tend to gain more weight over the years than those who eat breakfast regularly.
The new study suggests a possible mechanism by which this might occur.
“It may be that when you miss meals, and maybe particularly breakfast, your brain reward system is biased towards these high-calorie foods over the low-calorie foods,” Goldstone said, “and this would be an entirely appropriate response of the body in a defense to try to maintain calorie intake.”
“This may then be an explanation for why people who miss meals in an attempt to lose weight - something that is used by 30 percent to 40 percent of people trying to lose weight - may actually hinder their attempts to lose weight and actually may have an opposite effect and gain weight,” Goldstone said.
These results, he added, support current medical advice to eat a healthy breakfast to prevent weight gain and aid in weight loss.
•••
Ignored cholesterol blamed for heart attacks
Danish researchers said they have found the strongest evidence yet that an often ignored form of cholesterol can cause heart attacks.
They said people with higher levels of a little-understood form of cholesterol called lipoprotein (a), which varies up to a thousand fold from one person to another, were also more likely to have heart attacks.
Statins — taken by millions to cut heart attack and stroke risk — do not affect lipoprotein (a) but the findings may encourage the development of new cholesterol-lowering drugs, said Borge Nordestgaard of Copenhagen University Hospital.
The research, published in the Journal of the American Medical Association, showed that people with the highest lipoprotein (a) levels were two to three times more likely to have a heart attack than those with the lowest levels.
“We have shown that lipoprotein (a) is causing heart attacks,” Nordestgaard said in a telephone interview.
Lipoprotein (a) is one of several forms of cholesterol found in the blood, with levels determined almost entirely by genetics.
Statins lower levels of low-density lipoprotein, commonly known as “bad” cholesterol. Top-selling statins include Pfizer’s Lipitor, known chemically as atorvastatin, and AstraZeneca’s Crestor, or rosuvastatin.
“This study may explain why statins don’t work for some people,” Nordestgaard said.
To show the role of lipoprotein (a) role in heart attacks, the Danish team analyzed the genes of 45,000 men and women who gave blood samples for a large national survey starting in 1976, tested their lipoprotein (a) levels and then followed them until 2007.
People with the highest levels of this cholesterol had the most heart attacks, the study found. One certain genetic variation accounted for about a quarter of the cases of high lipoprotein (a).
“Lipoprotein (a) has been around for a long time as a risk factor but people hadn’t taken it too seriously because they didn’t think it caused heart attacks,” Nordestgaard said. “Now we show that, like LDL, it is causing heart attacks.”
One problem is that people have little control over the cholesterol, whose levels can vary up to a thousand-fold among individuals, Nordestgaard added.
Niacin, a vitamin often prescribed generically to lower cholesterol, also lowers lipoprotein (a) levels. It can cause uncomfortable flushing, however. Aspirin can also lower lipoprotein (a) levels.
Merck & Co markets a drug called Tredaptive in Europe that combines niacin with an anti-flushing agent but the drug has been rejected by U.S. health regulators.
Nordestgaard said he hopes the study will spur drugmakers to begin work on a new drug specifically aimed at lipoprotein (a) levels.
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